Acasă
/ Carti
/ Școală & Educație
/ Colorectal cancer. From genetics to prevention - Marilena Stoian

Colorectal cancer. From genetics to prevention - Marilena Stoian

Name: Colorectal cancer. From genetics to prevention - Marilena Stoian
Brand: Marilena Stoian
SKU: 112690
Price: 74.01 RON
Availability: InStock

Vândut de libris.ro

74,01 RON

Cel mai mic preț din ultimele 30 zile

În stoc la libris.ro Comandă direct la magazin

Vezi oferta la libris.ro

9 persoane urmăresc acest produs

Comandat de 50 ori în ultimele 7 zile

Produs 100% original

Colorectal cancer. From genetics to prevention - Marilena Stoian

74,01 RON

Vezi oferta la libris.ro Cumpără

Most human CRCs are thought to arise from adenomas (adenomatous polyps) that become dysplastic. Adenomatous polyps form in the colon when normal mechanisms regulating epithelial renewal are disrupted. Surface cells lining the intestine are continuously lost into the bowel lumen due to apoptosis and exfoliation and must be continuously replaced. Typically, proliferation occurs exclusively at the crypt base. As cells move towards the luminal surface, they cease proliferating and terminally differentiate. This ordered process is increasingly disrupted as adenomas increase in size, become dysplastic, and eventually attain invasive potential. Th hypothesis that invasive CRCs develop from intermediate precancerous precursors is supported by pathologic, epidemiologic, and observational clinical data. \n The adenoma carcinoma sequence postulates that colorectal carcinomas arise from precursor lesions, called adenomas. All adenomas contain dysplastic epithelium that arises from mutations in either the adenomatous polyposis coli gene or DNA mismatch repair genes. The earliest lesion detected with dysplasia is the aberrant crypt focus. Over time, as this lesion acquires additional mutations, it evolves into a classic adenomatous polyp. Adenomatous polyps are classified as tubular, tubulovillous, or villous. Generally, as polyps increase in size, the degree of dysplasia worsens, the villous component increases, the number of genetic abnormalities increases, and the likelihood of harboring invasive carcinoma increases. Carcinomas associated with DNA mismatch repair mutations are more likely to be poorly differentiated and incite a host lymphocytic response. These tumors seem to have a better prognosis, stage for stage, than typical colorectal carcinomas. \n Evidence suggests that subtypes of serrated polyps, particularly TSA and SSA/P, can lead to adenocarcinoma through the serrated pathway. Moreover, the data indicate that the SSA/P are the precursors of colorectal carcinoma by MSI and may be subject to rapid progression to malignancy. An important step to reduce the incidence of CRC initiated by the serrated pathway is to improve the detection of serrated polyps and to ensure their complete removal during endoscopy. Understanding of the so called serrated carcinogenesis pathway is an important step forward in expanding possibilities in the prevention of CRC.

Încă nu există recenzii pentru acest produs.

Lasă o recenzie

Nume Email (opțional) Rating Titlu (opțional) Mesaj Sunt de acord cu prelucrarea datelor mele conform GDPR.

Istoric preț

Istoric preț — ultimul an

Min 30z: 74,01 RON (OG 58/2022)

RON

Pe perioada zilelor fără schimbare, prețul rămâne identic cu ultima înregistrare.

Întrebări frecvente

Cum funcționează comanda pentru Colorectal cancer. From genetics to prevention - Marilena Stoian?

Apeși pe ofertă și ajungi direct pe libris.ro, magazinul partener care vinde Colorectal cancer. From genetics to prevention - Marilena Stoian — acolo pui produsul în coș și finalizezi plata. 4be nu procesează comenzi: rolul nostru e să aduni ofertele într-un singur loc și să alegi informat.

Produse similare

-10% Top

For You

Balonul este tulburat - Juliette Ttofa

PRP: 25,37 RON

22,83 RON -10%

În stoc

Colorectal cancer. From genetics to prevention - Marilena Stoian

Istoric preț

Istoric preț — ultimul an

Întrebări frecvente

Produse similare

Alte produse de la libris.ro

Alte produse Marilena Stoian

Ți-au plăcut aceste produse?

Cookies & confidențialitate

Setări cookies